October 27, 2021

Science

The world of science and technology

6 Reasons We Have to Say a Study Was “In Mice”

2 min read

6 Reasons We Have to Say a Study Was

A lot of our videos include the disclaimer “Mice aren’t people.” But why do we keep saying this, and if rodent studies aren’t effective, why do we keep using them?

Hosted by: Stefan Chin

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Sources:

Intro:
https://www.genome.gov/10005834/background-on-mouse-as-a-model-organism

Alzheimer’s disease:
https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease
https://www.nature.com/articles/d41586-018-05722-9
https://www.biospace.com/article/a-look-at-biogen-s-big-bet-on-the-holy-grail-of-science-and-mdash-alzheimer-s-/
http://investors.biogen.com/news-releases/news-release-details/biogen-and-eisai-discontinue-phase-3-engage-and-emerge-trials
https://www.nature.com/articles/s41586-019-1506-7

Multiple sclerosis:
https://medlineplus.gov/multiplesclerosis.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154595/
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(87)92863-7/fulltext
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586507/
https://www.degruyter.com/view/j/revneuro.2019.30.issue-1/revneuro-2018-0002/revneuro-2018-0002.xml

Hepatitis B:
https://www.cdc.gov/hepatitis/hbv/index.htm
https://www.nap.edu/catalog/4887/review-of-the-fialuridine-fiau-clinical-trials
http://discovermagazine.com/1994/mar/thecurethatkille345
https://www.ncbi.nlm.nih.gov/pubmed/16595656
http://perspectivesinmedicine.cshlp.org/content/5/12/a021451.full

Tuberculosis:

https://www.cdc.gov/tb/publications/faqs/qa_introduction.htm
https://medlineplus.gov/tuberculosis.html
https://www.ncbi.nlm.nih.gov/pubmed/11288517
https://www.ncbi.nlm.nih.gov/pubmed/20819249
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798013/
https://www.jimmunol.org/content/172/5/2731#sec-6

Saccharin:

https://academic.oup.com/annonc/article/15/10/1460/170200
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009921/
https://www.ncbi.nlm.nih.gov/pubmed/9428778
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591507/
https://www.niehs.nih.gov/news/newsroom/releases/2000/may15/index.cfm

Health Canada Approves Saccharin Sweeteners in Canada

Microbiome:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991899/
https://www.nature.com/articles/s41598-018-24342-x#Sec8

Stool transplants are now standard of care for recurrent C. difficile infections


https://dmm.biologists.org/content/8/1/1#sec-16
https://www.the-scientist.com/news-opinion/mouse-genetics-shape-the-gut-microbiome-more-than-their-environment-66238
https://www.eurekalert.org/pub_releases/2019-08/niod-mc072919.php

Closing:

Animal Research Continues to Save Lives

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